Byzepta: Diet and Exercise Mimetic Pill

Pathophysiology

GLP-1 downregulation

Glucagon-Like Peptide-1 (GLP-1) is an incretin hormone secreted by the intestinal L-cells in response to nutrient intake.

It plays a pivotal role in glucose homeostasis by enhancing insulin secretion in a glucose dependant manner, and enhances satiety.

GLP-1 downregulation, leads to insulin resistance causing metabolic dysregulation in PCOS manifesting its effects centrally and peripherally.

UCP-1 Downregulation

Uncoupling Protein-1 (UCP-1) is a mitochondrial protein predominantly expressed in Brown Adipose Tissue (BAT) which plays a crucial role in browning White Adipose Tissue (WAT), Women with PCOS often exhibit downregulation of UCP-1, contributing to weight gain and obesity, which exacerbate PCOS symptoms.

SHBG downregulation

Sex Hormone-Binding Globulin (SHBG) is a glycoprotein that binds to androgens like testosterone regulating their bioavailability.

PCOS is often characterized by reduced SHBG levels due to insulin resistance and obesity.

Low SHBG increases free testosterone, aggravating symptoms like hirsutism, acne, and androgenic alopecia.

Disclaimer: Above data / claim is based on the clinical evidence obtained from GLP-1 RA, UCP-1 and individual API molecules, Individual Results may vary*

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